Drug details

Orfadin (nitisinone capsules and oral suspension)

type of Metabolic & Endocrine, Other

Orfadin (nitisinone) is a hydroxyphenyl-pyruvate dioxygenase inhibitor used to treat a rare genetic condition called hereditary tyrosinemia type 1 (HT-1). HT-1 is a metabolic disorder that occurs when the body does not produce enough of an enzyme that breaks down proteins from certain foods. This condition occurs most often in babies. Orfadin works by helping to prevent the formation and build-up of several toxic substances that cause damage to the liver, kidneys, and nervous system. Many people using Orfadin do not have serious side effects.

This drug may have the following side effects:

• hives,
• difficulty breathing,
• swelling of your face, lips, tongue, or throat,
• nausea,
• upper stomach pain,
• loss of appetite,
• itching,
• dark urine,
• diarrhea,
• easy bruising,
• clay-colored stools,
• yellowing of the skin or eyes (jaundice),
• vision problems,
• eye pain,
• unusual bleeding (nose, mouth, vagina, or rectum),
• purple or red pinpoint spots under your skin,
• calluses, peeling, or hardened skin on the palms of your hands or the soles of your feet
• sudden change in behavior, ability, or development (sitting up, crawling, walking, talking),
• redness or swelling, burning, white or yellow patches on your eyes, and