Drug details

Lonsurf (trifluridine and tipiracil tablets)

type of Thymidine Phosphorylase Inhibitors

Lonsurf (trifluridine and tipiracil) is a combination of a nucleoside metabolic inhibitor and a thymidine phosphorylase inhibitor indicated for the treatment of patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy.

This drug may have the following side effects:

• hives,
• difficulty breathing,
• swelling of your face, lips, tongue, or throat,
• fever,
• easy bruising,
• unusual bleeding,
• pale skin,
• lightheadedness,
• shortness of breath,
• cold hands and feet,
• cough
• unusual tiredness,
• mouth sores,
• skin sores,
• purple or red spots under your skin,
• sore throat, and

The following drugs are related to Lonsurf, either as a replacement or used together:

• Adrucil (fluorouracil injection)
• Ayvakit (avapritinib tablets)
• Avastin (bevacizumab)
• Camptosar Injection (irinotecan hydrochloride)
• Xeloda (capecitabine)
• Eloxatin (oxaliplatin injection)
• Elzonris (tagraxofusp-erzs injection)
• Sancuso (granisetron transdermal system)