Drug details

Lupron Depot 3.75 mg (leuprolide acetate injection)

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Lupron Depot 3.75 mg (leuprolide acetate) is a synthetic gonadotropin-releasing hormone used in men to treat the symptoms of prostate cancer, and in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids. Lupron Depot 3.75 is also used to treat precocious (early-onset) puberty in both male and female children.

The drug is often used to treat Endometriosis , Prostate cancer .

This drug may have the following side effects:
  • nausea,
  • headache,
  • dizziness,
  • diarrhea,
  • weakness,
  • constipation,
  • chills,
  • stomach pain,
  • upset stomach,
  • trouble sleeping (insomnia),
  • tiredness,
  • depression,
  • increased sweating,
  • impotence,
  • vaginal itching or discharge,
  • acne,
  • hot flashes (flushing),
  • night sweats,
  • breast swelling or tenderness,
  • reduced sexual interest,
  • swelling of the ankles/feet,
  • clammy skin,
  • testicle pain,
  • joint or muscle aches or pain,
  • vaginal discomfort or dryness,
  • abnormal vaginal bleeding (in girls),
  • increased growth of facial hair,
  • skin redness/itching/scaling,
  • memory problems, or
  • injection site reactions (burning, pain, bruising, redness, stinging).
The following drugs are related to Lupron Depot 3.75 mg, either as a replacement or used together:
  • Plenaxis (abarelix)
  • Zytiga (abiraterone acetate tablets)
  • Alkeran (melphalan)
  • Axumin (fluciclovine f 18 intravenous injection)
  • Casodex (bicalutamide)
  • Xgeva (denosumab)
  • Eligard (leuprolide acetate)
  • Xtandi (enzalutamide capsules)
  • Eulexin (flutamide)
  • Fensolvi (leuprolide acetate for injectable suspension, for subcutaneous use)
  • Feraheme (ferumoxytol injection)
  • Zoladex 3.6 (goserelin acetate implant)
  • Vantas (histrelin acetate)
  • Supprelin LA (histrelin acetate subcutaneous implant)
  • Lupron Depot (leuprolide acetate for depot suspension)
  • Lupron Depot-Ped (leuprolide acetate for depot suspension)
  • Lupron Depot 22.5 (leuprolide acetate for depot suspension injection)
  • Lupaneta Pack (leuprolide acetate for depot suspension; norethindrone acetate tablets)
  • Viadur (leuprolide acetate implant)
  • Lupron (leuprolide acetate injection)
  • Nilandron (nilutamide tablets)
  • Trelstar (triptorelin pamoate for injectable suspension)
  • Trelstar Depot (triptorelin pamoate for injectable suspension)
  • Trelstar LA (triptorelin pamoate for injectable suspension)
The following supplements are related to Lupron Depot 3.75 mg, and may be used together with the drug:
  • Selenium (s.)
  • Strontium (s.)