Drug details

Spravato (esketamine nasal spray)

type of NMDA Antagonists, Antidepressants, Other

Spravato (esketamine) Nasal Spray is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist indicated, in conjunction with an oral antidepressant, for the treatment of treatment-resistant depression (TRD) in adults.

This drug may have the following side effects:

• hives,
• difficulty breathing,
• swelling of your face, lips, tongue, or throat,
• lightheadedness,
• chest pain,
• severe headache,
• blurred vision,
• painful urination,
• hallucinations,
• extreme drowsiness,
• pounding in your neck or ears, and
• sleep problems,
• seizure
• worsening depression,
• thoughts of hurting yourself,
• problems with thinking or memory,
• unusual changes in mood,
• unusual or unpleasant memories,
• increased urinating,
• urgent need to urinate,

The following drugs are related to Spravato, either as a replacement or used together:

• Xanax (alprazolam)
• Brintellix (vortioxetine tablets)
• Celexa (citalopram hydrobromide)
• Cymbalta (duloxetine hcl)
• Pristiq (desvenlafaxine extended-release tablets)
• Effexor (venlafaxine hydrochloride)
• Effexor XR (venlafaxine hydrochloride extended-release)
• Lexapro (escitalopram oxalate)
• Remeron (mirtazapine)
• Remeron SolTab (mirtazapine)
• Paxil (paroxetine hydrochloride)
• Seroquel (quetiapine fumarate)
• Seroquel XR (quetiapine fumarate extended-release tablets)
• Zoloft (sertraline hcl)
• Viibryd (vilazodone hydrochloride)