Drug details

Efudex (fluorouracil)

type of Dermatologics, Other, Antineoplastics, Topical

Efudex (fluorouracil) topical contains an antineoplastic antimetabolite used to treat scaly overgrowths of skin (actinic or solar keratoses). Efudex may also be used in the treatment of superficial basal cell carcinoma. It works by causing the death of cells that are growing fastest, such as abnormal skin cells. Efudex is available in generic form.

This drug may have the following side effects:

• burning,
• dryness,
• rash,
• swelling,
• trouble sleeping,
• pain,
• irritability,
• skin irritation,
• redness,
• scaling,
• temporary hair loss, or
• tenderness,
• peeling (exfoliation),
• changes in skin color at the site of application, or other local reactions.
  
• Other side effects of Efudex include eye irritation (e.g., stinging, watering),
  
• abnormal taste in the mouth.

The following drugs are related to Efudex, either as a replacement or used together:

• Aldara (imiquimod)
• Cervarix (human papillomavirus bivalent vaccine)
• Condylox Topical (podofilox topical solution)
• Cyramza (ramucirumab solution for intravenous infusion)
• Tafinlar (dabrafenib capsules)
• Fluorouracil Cream (fluorouracil cream)
• Gardasil (quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine)
• Zyclara (imiquimod cream)
• Yervoy (ipilimumab injection)
• Klisyri (tirbanibulin ointment)
• Mekinist (trametinib tablets)
• Veregen (sinecatechins ointment)

The following supplements are related to Efudex, and may be used together with the drug:

• Fish Oil (s.)
• Aloe (s.)
• Bovine Cartilage (s.)
• Inositol (s.)
• Oregon Grape (s.)
• Vitamin D (s.)