Drug details

Xigduo XR (dapagliflozin and metformin hcl extended-release tablets)

type of Antidiabetics, SGLT2 Inhibitors

Xigduo XR (dapagliflozin and metformin HCl) is a combination of two oral antihyperglycemic medications used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both dapagliflozin and metformin is appropriate.

This drug may have the following side effects:
  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • nausea,
  • loss of appetite,
  • yellowing of the skin or eyes (jaundice)
  • diarrhea,
  • fever,
  • pale skin,
  • lightheadedness,
  • chills,
  • stomach pain,
  • clay-colored stools,
  • dizziness,
  • blurred vision,
  • headache,
  • sweating,
  • tightness in the chest,
  • fast or shallow breathing,
  • hoarseness,
  • lower back or side pain,
  • seizures,
  • loss of consciousness,
  • anxiety,
  • slurred speech,
  • depression,
  • tremors,
  • nightmares,
  • fast heartbeat,
  • irritation,
  • difficulty swallowing,
  • cold sweats,
  • sleepiness,
  • general ill feeling,
  • increased appetite,
  • decreased appetite,
  • unusual tiredness or weakness,
  • shakiness,
  • bladder pain,
  • frequent urge to urinate,
  • pain, tenderness, redness, or swelling of the area between the anus and genitals,
  • joint pain, stiffness, or swelling,
  • cloudy urine,
  • redness of the skin,
  • bloody urine,
  • burning or painful urination,
  • change in color, amount, or odor of vaginal discharge,
  • muscle pain or cramping,
  • itches,
  • unpleasant breath odor,
  • vomiting blood, and
The following drugs are related to Xigduo XR, either as a replacement or used together:
  • Precose (acarbose)
  • Invokana (canagliflozin tablets)
  • Zegalogue (dasiglucagon injection)
  • Trulicity (dulaglutide injection, for subcutaneous use)
  • Trijardy XR (empagliflozin, linagliptin, and metformin hydrochloride extended-release tablets)
  • Lyumjev (insulin lispro-aabc injection)
  • Mounjaro (tirzepatide injection)