Drug details

Prempro, Premphase (conjugated estrogens, medroxyprogesterone acetate)

type of Estrogens/Progestins-HRT

Prempro (conjugated estrogens/medroxyprogesterone acetate) is a combination of conjugated estrogens, which is a mixture of female sex hormones, and another female hormone called progesterone used to treat the symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation, and to prevent thinning of the bones (osteoporosis).

The drug is often used to treat Osteoporosis .

This drug may have the following side effects:
  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • nausea,
  • vomiting,
  • shortness of breath,
  • confusion,
  • yellowing of the skin or eyes (jaundice),
  • pain spreading to your jaw or shoulder,
  • constipation,
  • sweating,
  • chest pain or pressure,
  • muscle weakness,
  • slurred speech,
  • problems with vision or balance,
  • coughing up blood,
  • increased thirst or urination,
  • memory problems,
  • sudden vision loss,
  • unusual vaginal bleeding,
  • sudden severe headache,
  • stabbing chest pain,
  • pain or warmth in one or both legs,
  • unusual behavior,
  • lump in your breast,
  • pelvic pain,
  • swelling or tenderness in your stomach,
  • bone pain, and
  • lack of energy
  • sudden numbness or weakness (especially one side of the body),
The following drugs are related to Prempro, Premphase, either as a replacement or used together:
  • Aci-Jel (vaginal jelly)
  • Atelvia (risedronate sodium delayed-release tablets)
  • Cenestin (synthetic conjugated estrogens)
  • Climara (estradiol transdermal)
  • Climara Pro (estradiol, levonorgestrel transdermal)
  • Premarin (conjugated estrogens)
  • Premarin Injection (conjugated estrogens for injection)
  • Divigel (estradiol gel)
  • Estratest (esterified estrogens and methyltestosterone)
  • Estrace (estradiol)
  • Estraderm (estradiol transdermal)
  • Estrasorb (estradiol topical emulsion)
  • Estring (estradiol vaginal ring)
  • Lopreeza (estradiol/norethindrone acetate tablets)
  • Menest (estrogens)
  • Ogen (estropipate)
  • Evista (raloxifene)
  • Fyavolv (norethindrone acetate and ethinyl estradiol tablets)
  • Prometrium (progesterone)
The following supplements are related to Prempro, Premphase, and may be used together with the drug:
  • Zinc (s.)
  • Magnesium (s.)
  • Calcium (s.)
  • Fish Oil (s.)
  • Vitamin D (s.)
  • Copper (s.)
  • Beta-Carotene (s.)
  • Dhea (s.)
  • St. John's Wort (s.)
  • Propionyl-L-Carnitine (s.)
  • Vitamin E (s.)
  • Kava (s.)
  • Soy (s.)
  • Strontium (s.)
  • Black Cohosh (s.)
  • Fluoride (s.)
  • Ipriflavone (s.)
  • Manganese (s.)