Drug details

Comtan (entacapone)

type of Antiparkinson Agents, COMT Inhibitors

Comtan (entacapone) is a COMT inhibitor used together with carbidopa and levodopa to treat "wearing-off" symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control.

This drug may have the following side effects:

• hives,
• difficulty breathing,
• swelling of your face, lips, tongue, or throat,
• fever,
• lightheadedness,
• confusion,
• sweating,
• weakness,
• agitation,
• unexplained muscle pain,
• very stiff (rigid) muscles,
• high fever,
• fast or uneven heartbeats,
• worsening of Parkinson symptoms,
• unusual thoughts or behavior,
• tremors,
• hallucination,
• tenderness,
• severe or ongoing diarrhea,
• restless muscle movements in your eyes, tongue, jaw, or neck,
• unusual tiredness, and
• dark-colored urine

The following drugs are related to Comtan, either as a replacement or used together:

• Symmetrel (amantadine hydrochloride)
• Kynmobi (apomorphine hydrochloride sublingual film)
• Cogentin (benztropine mesylate injection)
• Parlodel (bromocriptine mesylate)
• Lodosyn (carbidopa)
• Sinemet (carbidopa-levodopa)
• Eldepryl (selegiline hcl)
• Exelon (rivastigmine tartrate)
• Fluorodopa FDOPA (f18 injection)
• Inbrija (levodopa inhalation powder)
• Nourianz (istradefylline tablets)
• Kemadrin (procyclidine hydrochloride tablets)
• Mirapex ER (pramipexole dihydrochloride extended-release tablets)
• Ongentys (opicapone capsules)
• Requip (ropinirole hcl)
• Zelapar (selegiline hydrochloride)
• Tasmar (tolcapone)

The following supplements are related to Comtan, and may be used together with the drug:

• Black Tea (s.)
• Coenzyme Q-10 (s.)
• Green Tea (s.)
• Caffeine (s.)
• Vitamin E (s.)
• Coffee (s.)
• Creatine (s.)