Drug details

Ayvakit (avapritinib tablets)

type of Antineoplastic Tyrosine Kinase Inhibitors, PDGFR-alpha Inhibitors

Ayvakit (avapritinib) is a kinase inhibitor used to treat adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) harboring a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation, including PDGFRA D842V mutations. Ayvakit is also used to treat adult patients with advanced systemic mastocytosis (AdvSM), which includes patients with aggressive systemic mastocytosis (ASM), systemic mastocytosis with an associated hematological neoplasm (SM-AHN), and mast cell leukemia (MCL).

This drug may have the following side effects:

• hives,
• difficulty breathing,
• swelling of your face, lips, tongue, or throat,
• confusion,
• severe drowsiness,
• dizziness,
• vision problems,
• severe headache,
• hallucinations,
• unusual changes in mood or behavior,
• problems with speech, thinking, or memory,
• trouble sleeping, and
• severe weakness on one side of your body

The following drugs are related to Ayvakit, either as a replacement or used together:

• Camptosar Injection (irinotecan hydrochloride)
• Xeloda (capecitabine)
• Cyramza (ramucirumab solution for intravenous infusion)
• Taxotere (docetaxel for injection)
• Ellence (epirubicin hydrochloride)
• Eloxatin (oxaliplatin injection)
• Herceptin (trastuzumab)
• Herceptin Hylecta (trastuzumab and hyaluronidase-oysk injection, for subcutaneous use)
• Keytruda (pembrolizumab for injection)
• Lonsurf (trifluridine and tipiracil tablets)
• Paclitaxel Tablets (paclitaxel)