Drug details

Lotronex (alosetron hydrochloride)

type of IBS Agents, Selective 5-HT3 Receptor Antagonists

Lotronex (alosetron hydrochloride) blocks the action of a chemical called serotonin in the intestines, slowing the movement of stools (bowel movements) through the intestines and is used to treat severe, chronic irritable bowel syndrome (IBS) in women who have had diarrhea as the main symptom for at least 6 months, and should be used only in women who have tried other IBS treatments without success. Lotronex has not been shown to be effective in men with IBS.

This drug may have the following side effects:

• headache
• constipation
• gas
• bloating
• nausea
• hemorrhoids
• stomach upset or discomfort
• burping with heartburn
• or skin rash

The following drugs are related to Lotronex, either as a replacement or used together:

• Alosetron Hydrochloride Tablets (alosetron hydrochloride)
• Azulfidine EN-Tabs (sulfasalazine delayed release tablets)
• Bentyl (dicyclomine)
• Uceris (budesonide rectal foam)
• Constulose (lactulose solution, usp 10 g/15 ml)
• Donnatal Tablets (phenobarbital, hyoscyamine sulfate, atropine sulfate, scopolamine hydrobromide tablets)
• Viberzi (eluxadoline tablets)
• Imodium (loperamide hcl)
• Ixifi (infliximab-qbtx for injection, for intravenous use)
• Linzess (linaclotide capsules)

The following supplements are related to Lotronex, and may be used together with the drug:

• Blond Psyllium (s.)
• Wheat Bran (s.)
• Guar Gum (s.)
• Bifidobacteria (s.)